Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
Four compartment method as an efficacious and simplified technique for autologous non-cultured epidermal cell suspension preparation in vitiligo surgery: A randomized, active-controlled study.
Сравнительное исследованиеСтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Mrigpuri S, Razmi T M, Sendhil Kumaran M, Vinay K, Srivastava N, Parsad D
Аннотация
BACKGROUND: Autologous non-cultured epidermal cell suspension (NCES) is a successful surgical method for repigmentation of stable, refractory vitiligo. The need for laboratory equipment and expertise restricts its use to only a few research centres; hence, there is a requisite to simplify the technique of NCES preparation.
OBJECTIVES: To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES).
METHODS: Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.
RESULTS: Repigmentation outcome in 4C method as compared to lab-NCES was as follows: excellent (≥90%) repigmentation: 34% vs. 37%, P = 1.000, good (≥75%) repigmentation: 68% vs. 71%, P = 1.000; colour match: 59% vs. 54%, P = 0.794, patient satisfaction based on PGA score - 23.02 vs. 23.39 (P = 0.210) and major pattern of repigmentation (diffuse) - 76% vs. 71% (P = 0.618).
LIMITATIONS: Short follow-up period of 16 weeks.
CONCLUSION: Four compartment method is a simple and effective technique for vitiligo surgery in routine clinical practice.
OBJECTIVES: To evaluate the efficacy of NCES prepared by four compartment (4C) method compared to the laboratory-based method (lab-NCES).
METHODS: Anatomically based matched lesions (41 pairs) in 30 stable vitiligo patients were randomized to receive NCES prepared by 4C method or lab-NCES. Each patient was evaluated at 4, 8, 16 weeks after surgery by a blinded observer with regard to extent of repigmentation, colour match, patient global assessment (PGA) and pattern of repigmentation.
RESULTS: Repigmentation outcome in 4C method as compared to lab-NCES was as follows: excellent (≥90%) repigmentation: 34% vs. 37%, P = 1.000, good (≥75%) repigmentation: 68% vs. 71%, P = 1.000; colour match: 59% vs. 54%, P = 0.794, patient satisfaction based on PGA score - 23.02 vs. 23.39 (P = 0.210) and major pattern of repigmentation (diffuse) - 76% vs. 71% (P = 0.618).
LIMITATIONS: Short follow-up period of 16 weeks.
CONCLUSION: Four compartment method is a simple and effective technique for vitiligo surgery in routine clinical practice.