American journal of obstetrics and gynecology · 1994
Ovarian remnant syndrome: study in laboratory rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Minke T, DePond W, Winkelmann T, Blythe J
Аннотация
OBJECTIVES: This study was designed to answer two questions: (1) will devascularized ovarian rat tissue reimplant on intact or denuded peritoneal surfaces, and (2) will any revascularized tissue become functional, as evidenced by follicle formation and vaginal cornification?
STUDY DESIGN: A total of 110 young female Sprague-Dawley rats were divided into four study groups and a control group. Bilateral oophorectomy was performed on the rats in the first three study groups. In these groups the ovaries were sutured to the left peritoneal surfaces, where the devascularized tissue might become revascularized. The vascularized ovary was sutured to the right denuded peritoneal surface in the rats in group 4, and an oophorectomy was performed on the rats in the control group. The study animals were killed and evaluated at 3, 6, or 9 weeks postoperatively.
RESULTS: Seventy-five percent of the devascularized ovarian tissue revascularized. Forty-three percent of the viable ovarian tissue demonstrated follicular growth that increased with time to death. Thirty-seven percent of the rats showed the effects of estrogen on the vaginal epithelium.
CONCLUSIONS: This study indicates that devascularized ovarian tissue may reimplant on intact or abraded peritoneal surfaces, where in time it may resume functioning. These findings suggest that great care must be taken when using the laparoscope to collect ovarian specimens.
STUDY DESIGN: A total of 110 young female Sprague-Dawley rats were divided into four study groups and a control group. Bilateral oophorectomy was performed on the rats in the first three study groups. In these groups the ovaries were sutured to the left peritoneal surfaces, where the devascularized tissue might become revascularized. The vascularized ovary was sutured to the right denuded peritoneal surface in the rats in group 4, and an oophorectomy was performed on the rats in the control group. The study animals were killed and evaluated at 3, 6, or 9 weeks postoperatively.
RESULTS: Seventy-five percent of the devascularized ovarian tissue revascularized. Forty-three percent of the viable ovarian tissue demonstrated follicular growth that increased with time to death. Thirty-seven percent of the rats showed the effects of estrogen on the vaginal epithelium.
CONCLUSIONS: This study indicates that devascularized ovarian tissue may reimplant on intact or abraded peritoneal surfaces, where in time it may resume functioning. These findings suggest that great care must be taken when using the laparoscope to collect ovarian specimens.