ANZ journal of surgery · 2026
Outcomes of Patients With Severe Acute Pancreatitis Requiring Prolonged Intensive Care Admission at a Tertiary Centre: A Retrospective Cohort Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lew Chen, Jones Morgan, Pham Helen, Khaleel Mohammad, Hassum Hannah, Pilgrim Charles
Аннотация
BACKGROUND: Severe acute pancreatitis (SAP) can result in prolonged intensive care unit (ICU) admission and high mortality despite advances in supportive care. The outcomes of patients requiring extended ICU treatment remain poorly characterised. This study aimed to evaluate the clinical outcomes of patients with SAP requiring prolonged ICU admission at a tertiary referral centre.
METHODS: A retrospective cohort study was conducted at Alfred Health, Melbourne, including adult patients admitted with SAP over a 7-year period. Patients with an ICU length of stay > 14 days were compared with those admitted for ≤ 14 days. Data collected included demographics, aetiology, complications, interventions and in-hospital outcomes.
RESULTS: Of 691 admissions with acute pancreatitis, 60 patients (8.7%) required ICU admission for SAP, of whom 17 (28.3%) remained in ICU > 14 days. Alcohol-related aetiology was most common (33%). Patients with prolonged ICU stay experienced significantly higher rates of pancreatic necrosis (58.8% vs. 14.0%, p < 0.001), multiorgan failure (76.5% vs. 14.0%, p < 0.001) and respiratory failure (94.1% vs. 25.6%, p < 0.001). Mortality in the prolonged ICU group was higher (35.3% vs. 14.3%), though two-thirds ultimately survived to hospital discharge. Prolonged ICU stay was also associated with greater need for invasive interventions and extended total hospitalisation (median 48 vs. 14 days, p < 0.001).
CONCLUSION: Despite the complexity and duration of illness, two-thirds of patients with ICU stays beyond 2 weeks survived to discharge, indicating that extended organ support should not be viewed as futile. These findings underscore the importance of sustained multidisciplinary care and support continued active management in selected patients with severe disease.
METHODS: A retrospective cohort study was conducted at Alfred Health, Melbourne, including adult patients admitted with SAP over a 7-year period. Patients with an ICU length of stay > 14 days were compared with those admitted for ≤ 14 days. Data collected included demographics, aetiology, complications, interventions and in-hospital outcomes.
RESULTS: Of 691 admissions with acute pancreatitis, 60 patients (8.7%) required ICU admission for SAP, of whom 17 (28.3%) remained in ICU > 14 days. Alcohol-related aetiology was most common (33%). Patients with prolonged ICU stay experienced significantly higher rates of pancreatic necrosis (58.8% vs. 14.0%, p < 0.001), multiorgan failure (76.5% vs. 14.0%, p < 0.001) and respiratory failure (94.1% vs. 25.6%, p < 0.001). Mortality in the prolonged ICU group was higher (35.3% vs. 14.3%), though two-thirds ultimately survived to hospital discharge. Prolonged ICU stay was also associated with greater need for invasive interventions and extended total hospitalisation (median 48 vs. 14 days, p < 0.001).
CONCLUSION: Despite the complexity and duration of illness, two-thirds of patients with ICU stays beyond 2 weeks survived to discharge, indicating that extended organ support should not be viewed as futile. These findings underscore the importance of sustained multidisciplinary care and support continued active management in selected patients with severe disease.