DEN open · 2025
Endoscopic risk factors to inform early detection of gastric cancer after Helicobacter pylori eradication: Meta-analysis and systematic review.
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Kodama Masaaki, Handa Osamu, Sugimoto Mitsushige, Kotachi Takahiro, Kobayashi Masaaki, Take Susumu, Hoteya Shu, Mabe Katsuhiro, Murao Takahisa, Namikawa Ken, Kawai Takashi, Murakami Kazunari, Research committee for the Establishment of Risk Evaluation of Gastric Cancer after H. pylori Eradication in Endoscopic Findings, The Japanese Society for Helicobacter Research, Japan
Аннотация
OBJECTIVES: Helicobacter pylori eradication reduces but cannot eliminate the risk of gastric cancer (GC). The prevalence of post-eradication GC has been rising. Characterization of the endoscopic findings of post-eradication GC may facilitate its early detection. We performed a meta-analysis and systematic review to clarify endoscopic risk factors to accelerate the early diagnosis of post-eradication GC.
METHODS: Medline and PubMed were searched for randomized controlled trials, cohort studies, and case-control studies published in the English-language medical literature between January 1997 and July 2023. The included articles assessed the correlation between post-eradication GC and pre- and post-eradication endoscopic findings, and associated post-eradication GC with gastric atrophy, intestinal metaplasia (IM), map-like redness, and xanthoma.
RESULTS: A total of 963 articles were retrieved. In these articles, 66 papers were finally included, comprising randomized controlled trials, cohort studies, and case-control studies. The included articles addressed gastric atrophy (16 studies), IM (eight studies), map-like redness (six studies), and xanthoma (two studies). Risk ratio (RR) of incident post-eradication GC was 3.40 (95%confidence interval [95%CI]: 1.98-5.84; p < 0.001) in cases of severe atrophy, 5.38 (95%CI: 3.62-8.00) in cases of severe IM, 2.34 (95%CI: 1.16-4.68) in cases with post-eradication map-like redness, and 2.75 (95% CI: 1.78-4.26) in cases with xanthoma.
CONCLUSIONS: Endoscopic atrophy, IM, and xanthoma observed at pre- and post-eradication time points and post-eradication map-like redness were suggested as endoscopic risk factors for post-eradication GC. Further studies are needed to clarify the risk of post-eradication GC based on these risk factors.
METHODS: Medline and PubMed were searched for randomized controlled trials, cohort studies, and case-control studies published in the English-language medical literature between January 1997 and July 2023. The included articles assessed the correlation between post-eradication GC and pre- and post-eradication endoscopic findings, and associated post-eradication GC with gastric atrophy, intestinal metaplasia (IM), map-like redness, and xanthoma.
RESULTS: A total of 963 articles were retrieved. In these articles, 66 papers were finally included, comprising randomized controlled trials, cohort studies, and case-control studies. The included articles addressed gastric atrophy (16 studies), IM (eight studies), map-like redness (six studies), and xanthoma (two studies). Risk ratio (RR) of incident post-eradication GC was 3.40 (95%confidence interval [95%CI]: 1.98-5.84; p < 0.001) in cases of severe atrophy, 5.38 (95%CI: 3.62-8.00) in cases of severe IM, 2.34 (95%CI: 1.16-4.68) in cases with post-eradication map-like redness, and 2.75 (95% CI: 1.78-4.26) in cases with xanthoma.
CONCLUSIONS: Endoscopic atrophy, IM, and xanthoma observed at pre- and post-eradication time points and post-eradication map-like redness were suggested as endoscopic risk factors for post-eradication GC. Further studies are needed to clarify the risk of post-eradication GC based on these risk factors.