Proceedings of the National Academy of Sciences of the United States of America · 2018
Defining the sizes of airborne particles that mediate influenza transmission in ferrets.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zhou Jie, Wei Jianjian, Choy Ka-Tim, Sia Sin Fun, Rowlands Dewi K, Yu Dan, Wu Chung-Yi, Lindsley William G, Cowling Benjamin J, McDevitt James, Peiris Malik, Li Yuguo, Yen Hui-Ling
Аннотация
Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 µm, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.