Comfort and Ocular Surface Impact of Verofilcon A Daily Disposable Contact Lenses in Satisfied Senofilcon A Daily Disposable Lens Wearers: A Prospective Non-Interventional Study.

PURPOSE: To evaluate quality of life, comfort, and vision in long-term satisfied wearers of Senofilcon A daily disposable contact lens (SA) contact lenses after switching to Verofilcon A daily disposable contact lenses (VA), and to assess ocular surface parameters using an objective diagnostic platform C.DIAG (Quantel Medical, a brand of Lumibird, Clermont-Ferrand, France), a multimodal imaging platform for tear film assessment.

METHODS

This was a prospective, single-center, non-interventional study including 30 participants aged 20-40 years, all satisfied SA wearers. After 14 ± 2 days of vA wear, participants completed the CLDEQ-8 questionnaire and rated comfort and vision using a visual analog scale (VAS). Objective ocular surface assessments were performed using C.diag, including non-invasive tear break-up time (NIBUT), interferometry, blink analysis, and tear meniscus height. Statistical analysis was performed using paired Student's t-tests to compare subjective outcomes before and after the lens switch. Statistical significance was defined as p < 0.05.

RESULTS

The mean CLDEQ-8 score with va was 6.33 ± 2.82, with 56.7% of participants categorised as "excellent." VAS scores for vision and comfort with va were 87.3 ± 9.4 and 86.6 ± 10.8, respectively. No statistically significant deterioration in tear film parameters was observed after switching lenses (p > 0.05). NIBUT measurements were 11.5 ± 4.4 seconds (od) and 11.8 ± 4.3 seconds (os), with stable interferometry scores and consistent tear meniscus height observed.

CONCLUSION

VA daily disposable contact lenses provided high levels of subjective comfort and stable objective ocular surface parameters in previously satisfied daily disposable lens wearers. The C.DIAG device enabled standardized and non-invasive tear film analysis during contact lens wear. Further randomized and long-term studies are warranted to confirm these findings.