Fertility and sterility · 2014
Each small antral follicle in ovaries of women with polycystic ovary syndrome produces more antimüllerian hormone than its counterpart in a normal ovary: an observational cross-sectional study.
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Bhide Priya, Dilgil Merve, Gudi Anil, Shah Amit, Akwaa Charity, Homburg Roy
Аннотация
OBJECTIVE: To ascertain if subfertile women with polycystic ovary syndrome (PCOS) secrete more antimüllerian hormone (AMH) per antral follicle than control women.
DESIGN: Observational cross-sectional study.
SETTING: Fertility clinic.
PATIENT(S): A total of 438 women attending the fertility clinic over a period of 13 months from September 2012 to September 2013.
INTERVENTION(S): Serum concentrations of AMH and the total antral follicle count (AFC) were obtained from women attending the fertility clinic. The ratio of AMH/AFC for each subject was calculated. Women were categorized into three groups: PCOS, polycystic ovarian morphology (PCOM), and control. PCOS and PCOM were defined based on the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam consensus criteria.
MAIN OUTCOME MEASURE(S): The ratio of AMH/AFC for each subject in the three groups: PCOS, PCOM, and control.
RESULT(S): The median AMH/AFC ratios in the PCOS, PCOM, and control groups were 1.92, 1.13, and 1.00, respectively. The AMH/AFC ratio was significantly higher in the PCOS group compared with the PCOM and control groups (F[2,152] = 21.82). Women in the three groups were not statistically different regarding age, body mass index, earlier ovarian surgery, and smoking status.
CONCLUSION(S): Subfertile women with PCOS secrete significantly more AMH per antral follicle than women with PCOM only and control women.
DESIGN: Observational cross-sectional study.
SETTING: Fertility clinic.
PATIENT(S): A total of 438 women attending the fertility clinic over a period of 13 months from September 2012 to September 2013.
INTERVENTION(S): Serum concentrations of AMH and the total antral follicle count (AFC) were obtained from women attending the fertility clinic. The ratio of AMH/AFC for each subject was calculated. Women were categorized into three groups: PCOS, polycystic ovarian morphology (PCOM), and control. PCOS and PCOM were defined based on the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam consensus criteria.
MAIN OUTCOME MEASURE(S): The ratio of AMH/AFC for each subject in the three groups: PCOS, PCOM, and control.
RESULT(S): The median AMH/AFC ratios in the PCOS, PCOM, and control groups were 1.92, 1.13, and 1.00, respectively. The AMH/AFC ratio was significantly higher in the PCOS group compared with the PCOM and control groups (F[2,152] = 21.82). Women in the three groups were not statistically different regarding age, body mass index, earlier ovarian surgery, and smoking status.
CONCLUSION(S): Subfertile women with PCOS secrete significantly more AMH per antral follicle than women with PCOM only and control women.