Journal of the American Academy of Dermatology · 1992
Autologous grafting with noncultured melanocytes: a simplified method for treatment of depigmented lesions.
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Gauthier Y, Surleve-Bazeille J E
Аннотация
BACKGROUND: Achromic lesions on the trunk and the extremities often do not respond to treatment and little improvement is obtained in cases of segmental vitiligo.
OBJECTIVE: Transplantation of autologous noncultured melanocytes was performed to obtain a successful repigmentation.
METHODS: The grafting method is carried out in two steps: production of blisters on the depigmented lesions by freezing with liquid nitrogen and injection in each blister of a suspension of epidermal cells (mainly keratinocytes and melanocytes). The cellular suspension was obtained from samples of skin of the hair scalp after trypsinization.
RESULTS: Repigmentation was evident within 25 to 30 days. Coalescence of the pigmented areas was spontaneously observed or obtained after UVA stimulation. Patients with two types of leukoderma-vitiligo or nevus depigmentosus had successful repigmentation after transplantation of autologous noncultured melanocytes.
CONCLUSION: This technique appears to be an effective and simple method for treating patients with achromic areas lacking melanocytes.
OBJECTIVE: Transplantation of autologous noncultured melanocytes was performed to obtain a successful repigmentation.
METHODS: The grafting method is carried out in two steps: production of blisters on the depigmented lesions by freezing with liquid nitrogen and injection in each blister of a suspension of epidermal cells (mainly keratinocytes and melanocytes). The cellular suspension was obtained from samples of skin of the hair scalp after trypsinization.
RESULTS: Repigmentation was evident within 25 to 30 days. Coalescence of the pigmented areas was spontaneously observed or obtained after UVA stimulation. Patients with two types of leukoderma-vitiligo or nevus depigmentosus had successful repigmentation after transplantation of autologous noncultured melanocytes.
CONCLUSION: This technique appears to be an effective and simple method for treating patients with achromic areas lacking melanocytes.