The Annals of thoracic surgery · 2008
Bridge to lung transplantation through a pulmonary artery to left atrial oxygenator circuit.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Schmid Christof, Philipp Alois, Hilker Michael, Arlt Matthias, Trabold Benedikt, Pfeiffer Michael, Schmid Franz-Xaver
Аннотация
BACKGROUND: There is no mechanical device available to support patients with end-stage lung failure for weeks and months until appropriate donor organs for lung transplantation are available.
METHODS: In a 38-year-old female patient with primary pulmonary hypertension a paracorporeal artificial lung (PAL) system was placed parallel to the pulmonary circulation with connections to the pulmonary artery and to the left atrium. The key component of the PAL was a low-resistance membrane oxygenator.
RESULTS: After institution, the PAL had a blood flow of 3.5 L/min and created a PaO(2)/fraction of inspired oxygen ratio of 270, while the oxygenator was provided with oxygen 3 L/min. The pulmonary artery pressure declined by almost 50%. The PAL worked well over 62 days until appropriate donor lungs were available. With resuming more physical activity, an increased flow through the native lung augmented the fraction of unsaturated blood arriving at the left atrium, which mandated increasing oxygen flow to the PAL.
CONCLUSIONS: The data obtained with this case encourage further research into PAL systems, which may hopefully serve as a bridge to lung transplant device in appropriate patients in the future.
METHODS: In a 38-year-old female patient with primary pulmonary hypertension a paracorporeal artificial lung (PAL) system was placed parallel to the pulmonary circulation with connections to the pulmonary artery and to the left atrium. The key component of the PAL was a low-resistance membrane oxygenator.
RESULTS: After institution, the PAL had a blood flow of 3.5 L/min and created a PaO(2)/fraction of inspired oxygen ratio of 270, while the oxygenator was provided with oxygen 3 L/min. The pulmonary artery pressure declined by almost 50%. The PAL worked well over 62 days until appropriate donor lungs were available. With resuming more physical activity, an increased flow through the native lung augmented the fraction of unsaturated blood arriving at the left atrium, which mandated increasing oxygen flow to the PAL.
CONCLUSIONS: The data obtained with this case encourage further research into PAL systems, which may hopefully serve as a bridge to lung transplant device in appropriate patients in the future.