The fungus among us: Emerging and re-emerging fungal infections.

The landscape of fungal infections is rapidly evolving. The global rise in incidence of fungal disease and the increasing prevalence of antifungal resistance can be attributed to shifting host factors and changes in pathogen dynamics. Candida species have shown increasing rates of invasive disease. This is accompanied by a growing number of resistant species, including Candida auris. While dermatophytes remain the most common cause of fungal disease, novel resistant species are emerging as a major cause of recalcitrant infections. Endemic mycoses are expanding beyond their previously defined geographic ranges, with newly recognized genera such as Emergomyces. Similarly, more resistant mold infections are affecting an increasingly immunocompromised patient population. These opportunistic fungal pathogens continue to be a major source of worldwide morbidity and mortality. Addressing this challenge requires an improved understanding of fungal epidemiology, a commitment to protecting vulnerable patients, and the development of novel antifungal agents.