Wei sheng yan jiu = Journal of hygiene research · 2015
[Association between polymorphisms in the human dopamine D3 receptor gene and genetic susceptibility of essential tremor].
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Wang Feng, Zhao Zhong
Аннотация
OBJECTIVE: To study the association between polymorphisms in the human dopamine D3 receptor ( DRD3 ) gene and genetic susceptibility of essential tremor in different groups.
METHODS: The DRD3 gene polymorphism in ET and health control groups were analyzed with MscI restricted fragment length polymorphism ( RFLP). The results of PCR-RFLP were analyzed by using the statistical software.
RESULTS: No significant differences in alleles and allele frequency of MscI site at the DRD3 gene locus were observed between healthy control and different ET groups.
CONCLUSION: There is no association between polymorphisms MscI site at DRD3 and genetic susceptibility of ET.
METHODS: The DRD3 gene polymorphism in ET and health control groups were analyzed with MscI restricted fragment length polymorphism ( RFLP). The results of PCR-RFLP were analyzed by using the statistical software.
RESULTS: No significant differences in alleles and allele frequency of MscI site at the DRD3 gene locus were observed between healthy control and different ET groups.
CONCLUSION: There is no association between polymorphisms MscI site at DRD3 and genetic susceptibility of ET.