Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology · 2006
[Study on the treatment of nasal polyposis with bleomycin A5 local injection].
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Zhang Xianghong, Zou Jidong, Sun Bin, Liang Jianmin, Zhao Lin, Li Baoshu
Аннотация
OBJECTIVE: To study the treatment mechanism of nasal polyposis by locally injecting Bleomycin A5.
METHOD: The specimens from nineteen cases with nasal polyposis obtained before and after treatment with Bleomycin A5 were studied with immunohistochemical technique and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL).
RESULT: The apoptosis index (AI) of eosinophil was (20.53 +/- 7.66) % before treatment and (44.47 +/- 8.97) % after treatment. There was significantly difference between them (P < 0.01). The rate of TGF-beta1 positive expression in eosinophil after treatment (74.74 +/- 5.22) % was significantly lower than that before treatment (85.18 +/- 8.07) % (P < 0.05). The expression of TGF-beta1 in matrix was also decreased (P < 0.05).
CONCLUSION: Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis and reducing the expression of TGF-beta1.
METHOD: The specimens from nineteen cases with nasal polyposis obtained before and after treatment with Bleomycin A5 were studied with immunohistochemical technique and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL).
RESULT: The apoptosis index (AI) of eosinophil was (20.53 +/- 7.66) % before treatment and (44.47 +/- 8.97) % after treatment. There was significantly difference between them (P < 0.01). The rate of TGF-beta1 positive expression in eosinophil after treatment (74.74 +/- 5.22) % was significantly lower than that before treatment (85.18 +/- 8.07) % (P < 0.05). The expression of TGF-beta1 in matrix was also decreased (P < 0.05).
CONCLUSION: Bleomycin A5 could cure nasal polyposis by promoting eosinophil apoptosis and reducing the expression of TGF-beta1.