Gastrointestinal endoscopy · 2010
In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Hosoe Naoki, Kobayashi Taku, Kanai Takanori, Bessho Rieko, Takayama Tetsuro, Inoue Nagamu, Imaeda Hiroyuki, Iwao Yasushi, Kobayashi Seiki, Mukai Makio, Ogata Haruhiko, Hibi Toshifumi
Аннотация
BACKGROUND: The endocytoscopy system (ECS) is a new method to provide real-time super-magnifying microscopic imaging in vivo. Routine diagnosis of amebic colitis requires multiple tests that are both time consuming and costly.
OBJECTIVE: To determine the feasibility of ECS to directly detect the amebic parasites in vivo.
DESIGN: Prospective, single-center, pilot study.
SETTING: Tertiary-care university hospital.
PATIENTS: This study involved 5 patients who were suspected to have amebic colitis by conventional colonoscopy in our institute.
INTERVENTIONS: A super-magnifying ECS with 450 x magnification.
MAIN OUTCOME MEASUREMENTS: We compared ECS findings with those of conventional methods-serum antibody tests and histology of colon biopsy specimens.
RESULTS: We successfully visualized the amebic trophozoites in all 5 cases. In contrast, 3 specimens had positive results on serology, and 3 had positive histology results on hematoxylin and eosin staining.
LIMITATIONS: Pilot study with a limited number of patients. Findings were compared only with serology and histology findings.
CONCLUSIONS: ECS would be a useful tool for the prompt diagnosis of amebic colitis via the real-time in vivo visualization of amebic trophozoites.
OBJECTIVE: To determine the feasibility of ECS to directly detect the amebic parasites in vivo.
DESIGN: Prospective, single-center, pilot study.
SETTING: Tertiary-care university hospital.
PATIENTS: This study involved 5 patients who were suspected to have amebic colitis by conventional colonoscopy in our institute.
INTERVENTIONS: A super-magnifying ECS with 450 x magnification.
MAIN OUTCOME MEASUREMENTS: We compared ECS findings with those of conventional methods-serum antibody tests and histology of colon biopsy specimens.
RESULTS: We successfully visualized the amebic trophozoites in all 5 cases. In contrast, 3 specimens had positive results on serology, and 3 had positive histology results on hematoxylin and eosin staining.
LIMITATIONS: Pilot study with a limited number of patients. Findings were compared only with serology and histology findings.
CONCLUSIONS: ECS would be a useful tool for the prompt diagnosis of amebic colitis via the real-time in vivo visualization of amebic trophozoites.