[Significance of duodenitis and disorders of gall bladder motility in patients with diabetes mellitus].

Contractility of the gall bladder (by ultrasound criteria) and pancreatic enzyme excretion were considerably decreased in patients with diabetes mellitus of noninsulin dependent type in the presence of atrophic duodenitis, confirmed by endoscopy and histology, as compared to diabetic patients without duodenitis or with non-atrophic duodenitis. The data obtained were discussed with relation to a decrease in the excretion in atrophic duodenitis of cholecystokinin-pancreozymin (the main physiological stimulator of motility of the gall bladder and pancreatic enzyme excretion). It turned out that contractility of the gall bladder in patients with diabetic neuropathy was much less than that in diabetic patients without neuropathy provided all other conditions were the same. All the results obtained permitted better understanding of the essence, mechanisms and clinical meaning of gastroenterological disorders in patients with diabetes mellitus.