[Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium].

OBJECTIVE

To examine the expression of MUC5AC in human nasal polyp and inferior turbinate epithelium, to evaluate the relationship between MUC5AC and the increased mucous secretions in polyps and chronic hypertrophy rhinitis.

METHOD: With immunohistochemistry ABC and HE dyeing, twenty-seven polyps, nineteen chronic hypertrophy rhinitis and eleven normal inferior turbinates epithelium were applied to this study.

RESULT: The number of MUC5AC+ cells in nasal polyps and chronic hypertrophy rhinitis was significantly bigger than that in normal inferior turbinates (P < 0.05), and the MUC5AC+ cells were mainly concentrate on the goblet cells.

CONCLUSION

MUC5AC is highly expressed in epithelium of human polyps and chronic hypertrophy rhinitis inferior turbinates, and MUC5AC takes part in increasing secretion in polyps and chronic hypertrophy rhinitis.