Emerging infectious diseases · 2016
Global Escherichia coli Sequence Type 131 Clade with blaCTX-M-27 Gene.
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Matsumura Yasufumi, Pitout Johann D D, Gomi Ryota, Matsuda Tomonari, Noguchi Taro, Yamamoto Masaki, Peirano Gisele, DeVinney Rebekah, Bradford Patricia A, Motyl Mary R, Tanaka Michio, Nagao Miki, Takakura Shunji, Ichiyama Satoshi
Аннотация
The Escherichia coli sequence type (ST) 131 C2/H30Rx clade with the blaCTX-M-15 gene had been most responsible for the global dissemination of extended-spectrum β-lactamase (ESBL)-producing E. coli. ST131 C1/H30R with blaCTX-M-27 emerged among ESBL-producing E. coli in Japan during the late 2000s. To investigate the possible expansion of a single clade, we performed whole-genome sequencing for 43 Japan and 10 global ST131 isolates with blaCTX-M-27 (n = 16), blaCTX-M-14 (n = 16), blaCTX-M-15 (n = 13), and others (n = 8). We also included 8 ST131 genomes available in public databases. Core genome-based analysis of 61 isolates showed that ST131 with blaCTX-M-27 from 5 countries formed a distinct cluster within the C1/H30R clade, named C1-M27 clade. Accessory genome analysis identified a unique prophage-like region, supporting C1-M27 as a distinct clade. Our findings indicate that the increase of ESBL-producing E. coli in Japan is due mainly to emergence of the C1-M27 clade.