[Replacement hormonal therapy in correction of metabolic-trophic changes in ovarian failure syndrome].

Clinical and laboratory examination of 105 women was carried out: 46 of these were women with the ovarian exhaustion syndrome, aged 32 +/- 4.5, 42 healthy women aged 30 to 35 and 55 to 59, and 17 patients of a reproductive age after total oophorectomy. Metabolic changes were assessed from blood plasma lipid spectrum and osseous tissue compactness of the radial bone at its distal portion in two sites, 1/3 and 1/20 of its length. The efficacies of two drugs, presomen and anteovin, were compared in patients with ovarian exhaustion. Hypoestrogenism was shown to be one of the major pathogenetic factors in the development of dysmetabolic changes in women of a reproductive age with ovarian exhaustion. The author validates the desirability of substitution hormonal therapy in young women with prolonged estrogen deficiency in order to prevent the development of atherosclerosis and osteoporosis.