Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2011
[Serum levels of interferon-γ, interleukin-6 and tumor necrosis factor-α in patients with cerebral arterial stenosis].
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Liang Jian-tao, Wang Zhen-yu
Аннотация
OBJECTIVE: To investigate the relationship between interferon-γ(IFN-γ), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) and cerebral arterial stenosis and to compare serum levels of these inflammatory cytokines in different cerebral arteries stenosis groups.
METHODS: According to the stenotic site, patients with cerebral arteries stenosis were divided into intracranial stenosis group (n=26), extracranial stenosis group (n=30), intracranial and extracranial stenosis group (n=27), and group of stenosis in middle cerebral artery (n=25). And there were 33 samples in the control group. Blood serum IFN-γ, IL-6 and TNF-α levels were analyzed using enzyme linked immunosorbent assays (ELISA).
RESULTS: Serum IFN-γ and IL-6 levels were significantly increased in all the stenosis groups (P=0.000) as compared with the control group. But serum IFN-γ level had no significant difference between the two optional stenosis groups. And IL-6 level in intracranial stenosis group was lower than those in the other stenosis groups (P<0.05). In addition, we found that TNF-α of intracranial stenosis group (P=0.001) and MCA stenosis group (P=0.015) significantly increased as compared with the control group and the other two stenosis groups.
CONCLUSION: The results suggest that IFN-γ, IL-6 and TNF-α are possible to participate in the formation of certain cerebral arterial stenosis.
METHODS: According to the stenotic site, patients with cerebral arteries stenosis were divided into intracranial stenosis group (n=26), extracranial stenosis group (n=30), intracranial and extracranial stenosis group (n=27), and group of stenosis in middle cerebral artery (n=25). And there were 33 samples in the control group. Blood serum IFN-γ, IL-6 and TNF-α levels were analyzed using enzyme linked immunosorbent assays (ELISA).
RESULTS: Serum IFN-γ and IL-6 levels were significantly increased in all the stenosis groups (P=0.000) as compared with the control group. But serum IFN-γ level had no significant difference between the two optional stenosis groups. And IL-6 level in intracranial stenosis group was lower than those in the other stenosis groups (P<0.05). In addition, we found that TNF-α of intracranial stenosis group (P=0.001) and MCA stenosis group (P=0.015) significantly increased as compared with the control group and the other two stenosis groups.
CONCLUSION: The results suggest that IFN-γ, IL-6 and TNF-α are possible to participate in the formation of certain cerebral arterial stenosis.