Antioxidants (Basel, Switzerland) · 2024
Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Fiore Marco, Cambieri Chiara, Libonati Laura, Moret Federica, D'Andrea Edoardo, Di Certo Maria Grazia, Passananti Claudio, Gabanella Francesca, Corbi Nicoletta, Garibaldi Matteo, Chimenti Cristina, Alfarano Maria, Ferraguti Giampiero, Francati Silvia, Inghilleri Maurizio, Ceccanti Marco
Аннотация
Transthyretin-mediated amyloidosis (ATTR) is a systemic disease with protein precipitation in many tissues, mainly the peripheral nerve and heart. Both genetic (ATTRv, "v" for variant) and wild-type (ATTRwt) forms are known. Beyond the steric encumbrance, precipitated transthyretin seems to have a toxic effect. In this study carried out in men, we recruited 15 ATTRv patients, 7 ATTRv asymptomatic carriers, 14 ATTRwt patients and 10 young and 13 old healthy controls to evaluate the oxidative stress using FORD (Free Oxygen Radicals Defense) and FORT (Free Oxygen Radicals Test) analyses. ATTRv patients showed reduced FORD compared to ATTRwt and ATTRv asymptomatic carriers. FORD independently predicted the disease stage, with the early stages characterized by the highest consumption. These findings suggest a role for oxidative stress in the early stages of ATTRv.