Intensive care medicine · 2026
Sex, time, and disability status differences in mortality, multidimensional morbidity, and health care utilization: a secondary analysis of the Canadian RECOVER study.
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Burns Karen E A, Huszti Ella, Li Qixuan, Herridge Margaret S, Canadian Recover Program, the Canadian Critical Care Trials Group
Аннотация
PURPOSE: We assessed the association of sex with ICU mortality and longitudinal Functional Independence Measure (FIM) scores, Beck Depression Inventory-II (BDI-II), Impact of Event Scale-Revised (IES-R), and healthcare utilization to 1-year after hospital discharge.
METHODS: Secondary analysis of medical/surgical patients in the Canadian Towards RECOVER study.
RESULTS: Of 463 (185 females, 278 males) participants, significantly more males 45 (16.2%) versus females 20 (10.8%) died in the intensive care unit (ICU) [Hazard Ratio (HR) 1.8 (1.1, 3.1); p = 0.03]. Of 398 (165 females, 233 males) ICU survivors, 391 had FIM scores. Median FIM scores were significantly higher for male (versus female) survivors at 3-months (117 versus 106 points; p = 0.005), 6-months (119 versus 111.5 points; p = 0.005), and 12-months (121 versus 115 points; p = 0.003). Conversely, female (versus male) survivors had significantly higher BDI-II scores at 3-months [12.50 (7.0, 18.0) versus 9.0 (5.3, 14.8); p = 0.036], 6-months [11.8 (6.0, 17.8) versus 7.2 (3.0, 14.0); p = 0.009], 12-months [10.0 (4.0, 19.0) versus 11 (3.0, 26.3); p = 0.036] and higher IES-R scores at 3-months. Female survivors also experienced significantly more moderate (versus mild) [OR 6.9 (3.5, 13.7); p < 0.0001] and severe (versus moderate)[OR 40.9 (17.1, 98.2); p < 0.0001] depression. Whereas female ICU survivors had more rheumatology and nephrology specialty visits, males had more cardiology, endocrinology, surgical, and rehabilitation visits.
CONCLUSIONS: Although male ICU survivors experienced significantly higher ICU mortality, females experienced significantly lower longitudinal FIM scores and more frequent and severe depression.
METHODS: Secondary analysis of medical/surgical patients in the Canadian Towards RECOVER study.
RESULTS: Of 463 (185 females, 278 males) participants, significantly more males 45 (16.2%) versus females 20 (10.8%) died in the intensive care unit (ICU) [Hazard Ratio (HR) 1.8 (1.1, 3.1); p = 0.03]. Of 398 (165 females, 233 males) ICU survivors, 391 had FIM scores. Median FIM scores were significantly higher for male (versus female) survivors at 3-months (117 versus 106 points; p = 0.005), 6-months (119 versus 111.5 points; p = 0.005), and 12-months (121 versus 115 points; p = 0.003). Conversely, female (versus male) survivors had significantly higher BDI-II scores at 3-months [12.50 (7.0, 18.0) versus 9.0 (5.3, 14.8); p = 0.036], 6-months [11.8 (6.0, 17.8) versus 7.2 (3.0, 14.0); p = 0.009], 12-months [10.0 (4.0, 19.0) versus 11 (3.0, 26.3); p = 0.036] and higher IES-R scores at 3-months. Female survivors also experienced significantly more moderate (versus mild) [OR 6.9 (3.5, 13.7); p < 0.0001] and severe (versus moderate)[OR 40.9 (17.1, 98.2); p < 0.0001] depression. Whereas female ICU survivors had more rheumatology and nephrology specialty visits, males had more cardiology, endocrinology, surgical, and rehabilitation visits.
CONCLUSIONS: Although male ICU survivors experienced significantly higher ICU mortality, females experienced significantly lower longitudinal FIM scores and more frequent and severe depression.