Fertility and sterility · 1996
Serum 3 alpha-androstanediol-glucuronide is decreased in nonhirsute women with acne vulgaris.
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Joura E A, Geusau A, Schneider B, Söregi G, Huber J C
Аннотация
OBJECTIVE: To determine if acne vulgaris in women has a different pattern of androgen activity than hirsutism at the pilosebaceous unit.
DESIGN: Prospective clinical study.
SETTING: Outpatient clinic for gynecological endocrinology at a university hospital.
PATIENT(S): Twenty women suffering from mild or moderate acne vulgaris compared with 38 controls.
MAIN OUTCOME MEASURE(S): Serum androgens DHEAS, androstendione, T, including 3 alpha-androstanediol-glucuronide (3 alpha-diolG), the metabolite of 5 alpha-reductase activity.
RESULT(S): Serum 3 alpha-diolG was decreased in the acne groups depending on the grade of severity. No statistically significant differences were observed between the other androgens measured in acne patients and controls.
CONCLUSION(S): In contrast to hirsutism, acne is influenced directly by T and not by its 5 alpha-reduced metabolites. In female acne patients, 5 alpha-reductase activity appears to be reduced, which is reflected in decreased serum levels of 3 alpha-diolG. Consequently, 5 alpha-reductase inhibitors are most likely not promising candidates for acne therapy; a postulation that, however, requires further clinical investigation.
DESIGN: Prospective clinical study.
SETTING: Outpatient clinic for gynecological endocrinology at a university hospital.
PATIENT(S): Twenty women suffering from mild or moderate acne vulgaris compared with 38 controls.
MAIN OUTCOME MEASURE(S): Serum androgens DHEAS, androstendione, T, including 3 alpha-androstanediol-glucuronide (3 alpha-diolG), the metabolite of 5 alpha-reductase activity.
RESULT(S): Serum 3 alpha-diolG was decreased in the acne groups depending on the grade of severity. No statistically significant differences were observed between the other androgens measured in acne patients and controls.
CONCLUSION(S): In contrast to hirsutism, acne is influenced directly by T and not by its 5 alpha-reduced metabolites. In female acne patients, 5 alpha-reductase activity appears to be reduced, which is reflected in decreased serum levels of 3 alpha-diolG. Consequently, 5 alpha-reductase inhibitors are most likely not promising candidates for acne therapy; a postulation that, however, requires further clinical investigation.