Fertility and sterility · 1996
Dose-response effect of depot leuprolide acetate on serum androgens in hirsute women.
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Rittmaster R S, Arab D M, Lehman L
Аннотация
OBJECTIVE: To determine the dose of leuprolide acetate (LA) needed to maximally suppress serum androgens in hirsute women.
DESIGN: Prospective, dose-escalation study.
SETTING: Outpatient endocrinology clinic.
PATIENTS: Eight hyperandrogenic women with moderate to severe hirsutism.
INTERVENTIONS: A LA dose-response study was done in women receiving depot LA plus estrogen-progestin replacement.
MAIN OUTCOME MEASURES: Serum concentrations of T, androstenedione (A), and basal and GnRH-stimulated LH.
RESULTS: The lowest LA dose (3.75 mg/mo) suppressed serum T by 62% +/- 6% and A by 56% +/- 7%. No further decrease in serum androgens was seen with doses up to 15 mg/mo. Maximal suppression of basal and stimulated LH was also seen with the lowest dose of LA.
CONCLUSIONS: As opposed to results previously published in children with precocious puberty, the 3.75 mg dose of depot LA is sufficient to maximally suppress serum androgens in hyperandrogenic women.
DESIGN: Prospective, dose-escalation study.
SETTING: Outpatient endocrinology clinic.
PATIENTS: Eight hyperandrogenic women with moderate to severe hirsutism.
INTERVENTIONS: A LA dose-response study was done in women receiving depot LA plus estrogen-progestin replacement.
MAIN OUTCOME MEASURES: Serum concentrations of T, androstenedione (A), and basal and GnRH-stimulated LH.
RESULTS: The lowest LA dose (3.75 mg/mo) suppressed serum T by 62% +/- 6% and A by 56% +/- 7%. No further decrease in serum androgens was seen with doses up to 15 mg/mo. Maximal suppression of basal and stimulated LH was also seen with the lowest dose of LA.
CONCLUSIONS: As opposed to results previously published in children with precocious puberty, the 3.75 mg dose of depot LA is sufficient to maximally suppress serum androgens in hyperandrogenic women.