International journal of clinical pediatric dentistry · 2026
Comparative Evaluation of Anticariogenic Efficacy of Ocimum basilicum Varnish and Fluoride Varnish among 6-8-year-old School Children: A Double-blind Randomized Controlled Trial.
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Shankkari Siva, Ankola Anil V, Sankeshwari Roopali M, Nagamoti Mahantesh B, Ragu Kavitha, Parimala Yuvarani Kandasamy, Santhosh Varkey Nadakkavukaran, Varghese Anu Sara
Аннотация
BACKGROUND: Ocimum basilicum, commonly known as sweet basil, has been found to possess remineralization potential on enamel caries and antibacterial activity, making it suitable for formulation as a dental varnish for caries prevention.
AIM: To evaluate the anticariogenic efficacy of O. basilicum varnish among 6-8-year-old school children.
MATERIALS AND METHODS: A double-arm, parallel-group randomized controlled trial was conducted in a government primary school in Belagavi district, Karnataka. Forty children were randomly assigned to either the O. basilicum varnish group or the fluoride varnish group. Varnish application was carried out at baseline, after 1 month, and after 3 months. International Caries Detection and Assessment System (ICDAS) 1 score, number of initial carious lesions, and plaque Streptococcus mutans count were assessed at baseline and at the end of 4 months. Unpaired t-test and paired t-test were used to compare the differences within and between the groups, respectively. Statistical significance was set at p < 0.05.
RESULTS: An intragroup comparison revealed statistically significant differences (p < 0.001) within the groups in ICDAS 1 score, the number of initial carious lesions, and plaque S. mutans count. The fluoride varnish group demonstrated better reduction of ICDAS 1 score (p = 0.034) and number of initial carious lesions (p = 0.006). However, O. basilicum varnish showed more reduction of plaque S. mutans count (p < 0.001) than the fluoride varnish group.
CONCLUSION: Ocimum basilicum varnish possesses remineralization potential and better antibacterial activity against S. mutans. Henceforth, it can be used as an alternative to commercially available fluoride varnish.
CLINICAL SIGNIFICANCE: The dental varnish formulated from O. basilicum has proven to have anticariogenic potential with fewer adverse effects, endorsing its incorporation in clinical practice for the prevention of dental caries.
HOW TO CITE THIS ARTICLE: Shankkari S, Ankola AV, Sankeshwari RM, et al. Comparative Evaluation of Anticariogenic Efficacy of Ocimum basilicum Varnish and Fluoride Varnish among 6-8-year-old School Children: A Double-blind Randomized Controlled Trial. Int J Clin Pediatr Dent 2026;19(1):55-60.
AIM: To evaluate the anticariogenic efficacy of O. basilicum varnish among 6-8-year-old school children.
MATERIALS AND METHODS: A double-arm, parallel-group randomized controlled trial was conducted in a government primary school in Belagavi district, Karnataka. Forty children were randomly assigned to either the O. basilicum varnish group or the fluoride varnish group. Varnish application was carried out at baseline, after 1 month, and after 3 months. International Caries Detection and Assessment System (ICDAS) 1 score, number of initial carious lesions, and plaque Streptococcus mutans count were assessed at baseline and at the end of 4 months. Unpaired t-test and paired t-test were used to compare the differences within and between the groups, respectively. Statistical significance was set at p < 0.05.
RESULTS: An intragroup comparison revealed statistically significant differences (p < 0.001) within the groups in ICDAS 1 score, the number of initial carious lesions, and plaque S. mutans count. The fluoride varnish group demonstrated better reduction of ICDAS 1 score (p = 0.034) and number of initial carious lesions (p = 0.006). However, O. basilicum varnish showed more reduction of plaque S. mutans count (p < 0.001) than the fluoride varnish group.
CONCLUSION: Ocimum basilicum varnish possesses remineralization potential and better antibacterial activity against S. mutans. Henceforth, it can be used as an alternative to commercially available fluoride varnish.
CLINICAL SIGNIFICANCE: The dental varnish formulated from O. basilicum has proven to have anticariogenic potential with fewer adverse effects, endorsing its incorporation in clinical practice for the prevention of dental caries.
HOW TO CITE THIS ARTICLE: Shankkari S, Ankola AV, Sankeshwari RM, et al. Comparative Evaluation of Anticariogenic Efficacy of Ocimum basilicum Varnish and Fluoride Varnish among 6-8-year-old School Children: A Double-blind Randomized Controlled Trial. Int J Clin Pediatr Dent 2026;19(1):55-60.