Gastrointestinal endoscopy · 2011
Estimation of malignant potential of GI stromal tumors by contrast-enhanced harmonic EUS (with videos).
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Sakamoto Hiroki, Kitano Masayuki, Matsui Shigenaga, Kamata Ken, Komaki Takamitsu, Imai Hajime, Dote Kensaku, Kudo Masatoshi
Аннотация
BACKGROUND: Contrast-enhanced harmonic EUS (CEH-EUS) is a new sonographic technique that uses US contrast agents and depicts intratumoral vessels in real time.
OBJECTIVE: To evaluate whether assessment of tumor vascularity by CEH-EUS can predict the preoperative malignancy risk of GI stromal tumors (GISTs).
DESIGN: Prospective study to observe GIST vascularity.
SETTING: Kinki University School of Medicine.
PATIENTS: Between June 2007 and September 2009, 76 consecutive patients suspected of having subepithelial lesions underwent CEH-EUS.
INTERVENTION: CEH-EUS was performed by using a prototype echoendoscope in an extended pure harmonic detection mode.
MAIN OUTCOME MEASUREMENTS: Resected GIST specimens in 29 patients who underwent surgical resection were divided into high-grade (n=16) and low-grade (n=13) malignancy groups based on mitotic activity. The abilities of EUS-guided FNA and CEH-EUS to diagnose the malignant potential were compared. The sensitivities with which contrast-enhanced multidetector CT, power-Doppler EUS, and CEH-EUS detected intratumoral vessels in high-grade malignancy GISTs also were compared.
RESULTS: CEH-EUS identified irregular vessels and thereby predicted GIST malignancies with a sensitivity, specificity, and accuracy of 100%, 63%, and 83%, respectively. Diagnosis of high-grade malignancy GISTs by EUS-guided FNA had a sensitivity, specificity, and accuracy of 63%, 92%, and 81%, respectively. Contrast-enhanced multidetector CT, power-Doppler EUS, and CEH-EUS detected intratumoral vessels in high-grade malignancy GISTs with sensitivities of 31%, 63%, and 100%, respectively (P<.05).
LIMITATIONS: A single center was involved in this study.
CONCLUSIONS: CEH-EUS successfully visualized intratumoral vessels and may play an important role in predicting the malignancy risk of GISTs.
OBJECTIVE: To evaluate whether assessment of tumor vascularity by CEH-EUS can predict the preoperative malignancy risk of GI stromal tumors (GISTs).
DESIGN: Prospective study to observe GIST vascularity.
SETTING: Kinki University School of Medicine.
PATIENTS: Between June 2007 and September 2009, 76 consecutive patients suspected of having subepithelial lesions underwent CEH-EUS.
INTERVENTION: CEH-EUS was performed by using a prototype echoendoscope in an extended pure harmonic detection mode.
MAIN OUTCOME MEASUREMENTS: Resected GIST specimens in 29 patients who underwent surgical resection were divided into high-grade (n=16) and low-grade (n=13) malignancy groups based on mitotic activity. The abilities of EUS-guided FNA and CEH-EUS to diagnose the malignant potential were compared. The sensitivities with which contrast-enhanced multidetector CT, power-Doppler EUS, and CEH-EUS detected intratumoral vessels in high-grade malignancy GISTs also were compared.
RESULTS: CEH-EUS identified irregular vessels and thereby predicted GIST malignancies with a sensitivity, specificity, and accuracy of 100%, 63%, and 83%, respectively. Diagnosis of high-grade malignancy GISTs by EUS-guided FNA had a sensitivity, specificity, and accuracy of 63%, 92%, and 81%, respectively. Contrast-enhanced multidetector CT, power-Doppler EUS, and CEH-EUS detected intratumoral vessels in high-grade malignancy GISTs with sensitivities of 31%, 63%, and 100%, respectively (P<.05).
LIMITATIONS: A single center was involved in this study.
CONCLUSIONS: CEH-EUS successfully visualized intratumoral vessels and may play an important role in predicting the malignancy risk of GISTs.