Pagoda-Shaped Adhesive Microneedles Loaded with Ketorolac for Aortic Dissection Treatment.

Aortic dissection is a serious health risk and has led to interest in creating effective drug treatments like ketorolac. However, conventional administration techniques lack specificity, which limits their effectiveness and may result in adverse effects. A microneedle patch system (MNPS) offers a minimally invasive, pain-free alternative with a high capacity for drug delivery, but there is still a gap in the direction of treating aortic dissection. Here, we present a novel biodegradable MNPS with a pagoda-shaped structure designed for drug loading. These MNPS were fabricated using a stepwise mold replication method, with the medication embedded in the top layer of the MNPS. The double-layered pagoda structure enhances MNPS adhesion, enabling it to withstand the impact of aortic blood flow and enhancing drug targeting. In conclusion, our pagoda MNPS introduces a new approach for treating aortic dissection, providing hope for affected patients.