Fertility and sterility · 1992
Chronic high-dosage androgen administration to ovulatory women does not alter adrenocortical steroidogenesis.
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Futterweit W, Green G, Tarlin N, Dunaif A
Аннотация
OBJECTIVE: To evaluate the role of chronic long-term exogenous androgen administration to normal ovulatory women on adrenal steroidogenesis.
DESIGN: Prospective study of four consecutive female-to-male transsexuals before and during chronic testosterone (T) therapy.
SETTING: Clinical Research Center of the Mount Sinai Medical Center.
PATIENTS: Four female-to-male transsexuals were studied before and during 6 to 12 months of chronic T enanthate therapy for desired virilization. All four subjects were ovulatory before treatment. Adrenocorticotropic hormone (ACTH) testing was performed before, and 6 and 12 months of androgen therapy and various adrenal androgens as well as precursor:product pairs were evaluated as an index of specific adrenocortical biosynthetic defects.
RESULTS: Baseline and 1 hour after 0.25 mg ACTH intravenously, adrenal androgen levels as well as adrenal precursor/product pairs demonstrated no difference before and during chronic T treatment. Studies included determinations of plasma 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone, androstenedione, 11-deoxycortisol, and cortisol.
CONCLUSION: It is concluded that chronic hypertestosteronemia does not alter adrenal steroidogenesis.
DESIGN: Prospective study of four consecutive female-to-male transsexuals before and during chronic testosterone (T) therapy.
SETTING: Clinical Research Center of the Mount Sinai Medical Center.
PATIENTS: Four female-to-male transsexuals were studied before and during 6 to 12 months of chronic T enanthate therapy for desired virilization. All four subjects were ovulatory before treatment. Adrenocorticotropic hormone (ACTH) testing was performed before, and 6 and 12 months of androgen therapy and various adrenal androgens as well as precursor:product pairs were evaluated as an index of specific adrenocortical biosynthetic defects.
RESULTS: Baseline and 1 hour after 0.25 mg ACTH intravenously, adrenal androgen levels as well as adrenal precursor/product pairs demonstrated no difference before and during chronic T treatment. Studies included determinations of plasma 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone, androstenedione, 11-deoxycortisol, and cortisol.
CONCLUSION: It is concluded that chronic hypertestosteronemia does not alter adrenal steroidogenesis.
Предметные рубрики MeSH
17-alpha-HydroxypregnenoloneAdrenal CortexAdrenal Cortex HormonesAdrenocorticotropic HormoneAdultAndrogensAndrostenedioneCortodoxoneDehydroepiandrosteroneDose-Response Relationship, DrugFemaleHumansHydrocortisoneInjections, IntravenousMiddle AgedOvulationProspective StudiesStatistics as TopicTestosteroneTranssexualism