The Journal of the Association of Physicians of India · 2025
Clinical Biochemical Profile and Outcomes of Cerebral Venous Thrombosis in Puerperal and Nonpuerperal Presentation: A Prospective Observation Study from Northwest India.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kumar Kamlesh, Dhankar Kailash, Kumawat Rohit
Аннотация
BACKGROUND: Cerebral venous thrombosis (CVT) is a rare but treatable cause of stroke, predominantly affecting younger individuals, particularly women during the puerperal period. Despite increased recognition through advanced imaging, clinical diagnosis remains challenging due to its diverse presentation and varying etiological factors.
OBJECTIVE: To evaluate the clinical profile, etiological factors, treatment outcomes, and prognosis of CVT patients, with a focus on comparing puerperal and nonpuerperal cases in a tertiary care setting in Northwest India.
MATERIALS AND METHODS: This prospective observational study included 80 adult patients diagnosed with CVT via computed tomography venography (CTV) or magnetic resonance venography (MRV) over a 2-year period. Participants were categorized into male, puerperal female, and nonpuerperal female groups. Detailed clinical, laboratory, and radiological evaluations were performed. Modified Rankin Scale (mRS) was used to assess neurological outcomes. Statistical analyses were conducted using analysis of variance (ANOVA) and Chi-squared tests with significance at p < 0.05.
RESULTS: Puerperal females were younger than other groups. Common symptoms included headache (85%), seizures (45%), and focal deficits (47.5%). Hyperhomocysteinemia (65%) and vitamin B12 deficiency (51.25%) were prevalent, particularly among males and nonpuerperal females. Anemia was significantly more common in females. No significant difference was noted in clinical outcomes across groups. Poor prognosis was associated with Glasgow Coma Scale (GCS) <8, focal deficits, and low vitamin B12 levels. In-hospital mortality was 6.25%; 97% of survivors had favorable outcomes (mRS <3) at 3 months.
CONCLUSION: CVT in Northwest India affects a significant number of males and nonpuerperal females. Nutritional deficiencies, particularly vitamin B12 and anemia, play a crucial role. Early diagnosis and appropriate anticoagulation therapy are critical for favorable outcomes.
OBJECTIVE: To evaluate the clinical profile, etiological factors, treatment outcomes, and prognosis of CVT patients, with a focus on comparing puerperal and nonpuerperal cases in a tertiary care setting in Northwest India.
MATERIALS AND METHODS: This prospective observational study included 80 adult patients diagnosed with CVT via computed tomography venography (CTV) or magnetic resonance venography (MRV) over a 2-year period. Participants were categorized into male, puerperal female, and nonpuerperal female groups. Detailed clinical, laboratory, and radiological evaluations were performed. Modified Rankin Scale (mRS) was used to assess neurological outcomes. Statistical analyses were conducted using analysis of variance (ANOVA) and Chi-squared tests with significance at p < 0.05.
RESULTS: Puerperal females were younger than other groups. Common symptoms included headache (85%), seizures (45%), and focal deficits (47.5%). Hyperhomocysteinemia (65%) and vitamin B12 deficiency (51.25%) were prevalent, particularly among males and nonpuerperal females. Anemia was significantly more common in females. No significant difference was noted in clinical outcomes across groups. Poor prognosis was associated with Glasgow Coma Scale (GCS) <8, focal deficits, and low vitamin B12 levels. In-hospital mortality was 6.25%; 97% of survivors had favorable outcomes (mRS <3) at 3 months.
CONCLUSION: CVT in Northwest India affects a significant number of males and nonpuerperal females. Nutritional deficiencies, particularly vitamin B12 and anemia, play a crucial role. Early diagnosis and appropriate anticoagulation therapy are critical for favorable outcomes.