Nuclear Protein in Testis (NUT) Carcinoma With Nasopharyngeal and Intracranial Involvement: A Case Report.

Nuclear protein in testis (NUT) carcinoma is a rare and aggressive malignancy characterized by NUT gene rearrangement. Previously classified as NUT midline carcinoma, this malignancy was reclassified to NUT carcinoma in order to reflect that it can occur outside midline structures of the body. This case report follows a 43-year-old male presenting with a nasopharyngeal mass invading the frontal brain region, ultimately diagnosed as NUT carcinoma. Here, we detail the clinical and molecular characteristics of this tumor to contribute to the growing body of literature on this rare malignancy, while acknowledging potential diagnostic challenges and therapeutic considerations.