-455A Allele May Be a Protective Locus for Aseptic Lower Extremity Superficial Thrombophlebitis.

Objective

We designed a prospective experiment to explore the whole promoter region of fibrinogen B β (FGB) with the intent to detect all single nucleotide polymorphisms (SNPs) in this region and their impact on the susceptibility of aseptic lower extremity superficial thrombophlebitis (STP).

Methods

The experiment was conducted prospectively and randomized. Thirty-four idiopathic STP patients and 50 healthy people were recruited, respectively, as case and control groups. The whole FGB promoter was gene sequenced.

Results

From upstream to downstream of the promoter, a totally 6 SNPs-rs1800789 (-1420G/A), rs2227389 (-993C/T), rs1800791 (-854G/A), rs1800790 (-455G/A), rs1800788 (-249C/T), and rs1800787 (-148C/T) were detected via gene sequencing. A statistical difference was found in the -455A allele (rs1800790) between the two groups (p < 0.05, odds ratio = 0.368, 95% confidence interval: 0.093 - 0.852), while no statistical difference as for the other five SNPs (all p > 0.05).

Conclusions

The 455A allele may be a protective locus for the onset of STP. However, due to the low incidence of idiopathic STP, multiple verification tests are still needed.