Failure of systemically administered corticosteroids to suppress UVB-induced delayed erythema.

The effects of systemic corticosteroids on ultraviolet-induced delayed erythema were observed in a double-blind controlled study. The backs of human volunteers were irradiated with ultraviolet B (UVB) sources, and subsequent response was observed while ingesting prednisone (80 mg by mouth for 3 days) of placebo. Prednisone given 24 hours before, immediately after, 24 hours or 48 hours after exposure did not increase the redness, edema, or tenderness of the exposed sites.