Natural product research · 2019
Modulation of the resistance to norfloxacin in Staphylococcus aureus by Bauhinia forficata link.
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de Sousa Jonas Nascimento, de Oliveira Aylla Beatriz Melo, Ferreira Andressa Kelly, Silva E, de Sousa Leide Maria Soares, França Rocha Melissa Carvalho, de José Pinto, Júnior Siqueira, William Kaatz Glenn, da Silva Almeida Jackson Roberto Guedes, de Souza João Sammy Nery, Medeiros Barreto Humberto
Аннотация
Microdilution assays were performed in order to evaluate the antimicrobial activity of the ethanoic extract from the leaves of Bauhinia forficate (EEBF) against different microorganisms. The extract did not present inner antimicrobial activities against the tested strains. However, EEBF was able to modulate the norfloxacin-resistance against Staphylococcus aureus SA1199-B that overproduce the NorA efflux pump, once sub-inhibitory concentrations of EEBF reduced the minimal inhibitory concentratio of the norfloxacin in 87.5%. This modulatory effect was also found when the antibiotic was replaced by ethidium bromide, suggesting that EEBF acts probably by inhibition of NorA, allowing the antibiotic accumulation intracellularly, and making the line more sensitive. These results point out the EEBF potential as a source of NorA inhibitors that could be used in combination with norfloxacin for treatment of infections caused by multidrug-resistant S. aureus.