[Invasive pulmonary aspergillosis during the treatment of acute leukaemia (3 case report)].

The authors describe 3 patients with confirmed diagnosis of invasive pulmonary aspergillosis (IPA) during the treatment of acute leukaemia in the period July-September 1987. High statistic significance of previous incidence of the disease, high fungal contamination and epidemiologic relationship between cases point at the epidemic. All patients were treated with amphotericin B; two patients died and the third was cured with intensive 6-month--treatment of amphotericin B in the total dose of 4 grams. It is necessery to introduce amphotericin B in therapy of every febrile patient in prolonged granulocytopenia not responsive to 2 combinations of antibiotics after 4 days and persistently looking for radiologic, microbiologic, serologiic and histopathologic evidence of aspergillus infection. In addition to prolonged granulocytopenia high contamination of air with aspergilli is necessery for an epidemic of invasive pulmonary aspergillosis.