Allergy · 2022
Fungal exposome, human health, and unmet needs: A 2022 update with special focus on allergy.
ОбзорСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Vitte Joana, Michel Moïse, Malinovschi Andrei, Caminati Marco, Odebode Adeyinka, Annesi-Maesano Isabella, Caimmi Davide Paolo, Cassagne Carole, Demoly Pascal, Heffler Enrico, Menu Estelle, Nwaru Bright I, Sereme Youssouf, Ranque Stéphane, Raulf Monika, Feleszko Wojciech, Janson Christer, Galán Carmen, EAACI Task Force on Allergic Bronchopulmonary Aspergillosis
Аннотация
Humans inhale, ingest, and touch thousands of fungi each day. The ubiquity and diversity of the fungal kingdom, reflected by its complex taxonomy, are in sharp contrast with our scarce knowledge about its distribution, pathogenic effects, and effective interventions at the environmental and individual levels. Here, we present an overview of salient features of fungi as permanent players of the human exposome and key determinants of human health, through the lens of fungal allergy and other fungal hypersensitivity reactions. Improved understanding of the fungal exposome sheds new light on the epidemiology of fungal-related hypersensitivity diseases, their immunological substratum, the currently available methods, and biomarkers for environmental and medical fungi. Unmet needs are described and potential approaches are highlighted as perspectives.