Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2024
Effects of multiple apheresis platelet donations for the iron nutrition condition and platelet parameters of blood donors in China: A meta-analysis study.
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Sun Quan, Wu Liying, Shen Yao, Wang Le, Shen Xiujuan
Аннотация
BACKGROUND: Apheresis platelets is a common platelets collection method with high purity and relatively few adverse reactions. This study aimed to explore the effects of multiple apheresis platelet donations on the condition of iron nutrition and platelet parameters of donors in China.
METHODS: Eligible studies were selected from PubMed, EMBASE, Wanfang, CQVIP, and the Chinese National Knowledge Infrastructure (CNKI) databases. Pooled serum ferritin (SF), serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit (PCT) were analyzed by weighted mean difference (WMD). Heterogeneity was detected by the Cochran Q test and I2 statistical test.
RESULTS: Pooled SF (WMD =-20.837, 95 % CI = -26.403 - -15.271) and SI (WMD = -3.828, 95 % CI = -6.516 - -1.139) were significantly decreased; while TRF (WMD = 0.821, 95 % CI = 0.271-1.371) and sTfR (WMD = 0.846, 95 % CI = 0.442-1.250) were increased by multiple apheresis platelet donations. PLT (WMD = 14.894, 95 % CI = 2.574-27.215) and PCT (WMD = 0.035, 95 % CI = 0.005-0.064) were increased, but MPV (WMD = -0.359, 95 % CI = -0.571 - -0.147) was reduced by multiple donations. Subgroup analysis indicated study design is a source of heterogeneity.
CONCLUSION: Multiple apheresis platelets could lead to iron deficiency and suppress platelet function in comparison with first-time apheresis platelets.
METHODS: Eligible studies were selected from PubMed, EMBASE, Wanfang, CQVIP, and the Chinese National Knowledge Infrastructure (CNKI) databases. Pooled serum ferritin (SF), serum iron (SI), transferrin (TRF), soluble transferrin receptor (sTfR), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit (PCT) were analyzed by weighted mean difference (WMD). Heterogeneity was detected by the Cochran Q test and I2 statistical test.
RESULTS: Pooled SF (WMD =-20.837, 95 % CI = -26.403 - -15.271) and SI (WMD = -3.828, 95 % CI = -6.516 - -1.139) were significantly decreased; while TRF (WMD = 0.821, 95 % CI = 0.271-1.371) and sTfR (WMD = 0.846, 95 % CI = 0.442-1.250) were increased by multiple apheresis platelet donations. PLT (WMD = 14.894, 95 % CI = 2.574-27.215) and PCT (WMD = 0.035, 95 % CI = 0.005-0.064) were increased, but MPV (WMD = -0.359, 95 % CI = -0.571 - -0.147) was reduced by multiple donations. Subgroup analysis indicated study design is a source of heterogeneity.
CONCLUSION: Multiple apheresis platelets could lead to iron deficiency and suppress platelet function in comparison with first-time apheresis platelets.