Nanomedicine (London, England) · 2018
Highly efficient and biocompatible nanoparticle-based photosensitizer for treatment of acne vulgaris.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Wang Peng, Tang Hong, Zhang Peng
Аннотация
AIM: Nanoparticle-based photosensitizers containing silver core and mesoporous silica shell with hematoporphyrin IX embedded were developed to treat vulgaris photodynamically.
MATERIALS & METHODS: The hybrid photosensitizers were dispersed in 30% polyethylene glycol (PEG-200) solution and used for the photodynamic treatment of Staphylococcus epidermidis and Propionibacterium acnes under the illumination of a portable LED (∼410 nm).
RESULTS: After a 5 min illumination by the LED, the hybrid photosensitizers of 50 μg/ml displayed killing efficacy of approximately 5-log for S. epidermidis and approximately 4-log for P. acnes. Results indicated that hybrid photosensitizers in PEG-200 matrix perform better than in deionized (DI) water (∼1-log increase in killing efficacy).
CONCLUSION: Under short illumination of a portable LED, hybrid photosensitizers demonstrated immense potential for treatment of acne vulgaris without involving antibiotics.
MATERIALS & METHODS: The hybrid photosensitizers were dispersed in 30% polyethylene glycol (PEG-200) solution and used for the photodynamic treatment of Staphylococcus epidermidis and Propionibacterium acnes under the illumination of a portable LED (∼410 nm).
RESULTS: After a 5 min illumination by the LED, the hybrid photosensitizers of 50 μg/ml displayed killing efficacy of approximately 5-log for S. epidermidis and approximately 4-log for P. acnes. Results indicated that hybrid photosensitizers in PEG-200 matrix perform better than in deionized (DI) water (∼1-log increase in killing efficacy).
CONCLUSION: Under short illumination of a portable LED, hybrid photosensitizers demonstrated immense potential for treatment of acne vulgaris without involving antibiotics.