Immunobiology · 2026
Increased Granzyme K+ CD8+ T cells and senescent subset in Behçet's disease.
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Lee Heera, Lee Soo-Jin, Park Young Joon, Kim Han Seul, Lee Eun-So, Park Sun
Аннотация
OBJECTIVES: Behçet's disease (BD) is a chronic inflammatory condition with immune system dysregulation. Recent evidence suggests proinflammatory roles of extracellular granzyme K (GzmK), particularly in aged immune cells. This study investigated GzmK-expressing CD8+ T cells and their senescent subset in BD pathology.
METHODS: We analysed lymphocyte subsets in blood samples from 19 active BD (aBD), 19 inactive BD (iaBD), and 19 healthy controls (HC) using flow cytometry and granzymes, as well as IL-6 using enzyme-linked immunosorbent assay.
RESULTS: Active BD patients showed significantly higher serum GzmK levels and GzmK+CD8+ T cells with advanced differentiation markers. GzmK+CD8+ T cells positively correlated with TNF-α+ and IFN-γ+ lymphocytes. The senescent subset (GzmK+CD27-CD28-CD57+CD8+) specifically correlated with TNF-α+ lymphocytes, indicating involvement in TNF-α-centered inflammatory pathways.
CONCLUSION: GzmK+CD8+ T cells and their senescent counterparts are not merely biomarkers of disease activity but may function as extracellular proinflammatory effectors that amplify the TNF-α-mediated inflammatory loop in BD. Targeting the GzmK-senescence axis represents a promising therapeutic strategy for managing chronic inflammation in BD.
METHODS: We analysed lymphocyte subsets in blood samples from 19 active BD (aBD), 19 inactive BD (iaBD), and 19 healthy controls (HC) using flow cytometry and granzymes, as well as IL-6 using enzyme-linked immunosorbent assay.
RESULTS: Active BD patients showed significantly higher serum GzmK levels and GzmK+CD8+ T cells with advanced differentiation markers. GzmK+CD8+ T cells positively correlated with TNF-α+ and IFN-γ+ lymphocytes. The senescent subset (GzmK+CD27-CD28-CD57+CD8+) specifically correlated with TNF-α+ lymphocytes, indicating involvement in TNF-α-centered inflammatory pathways.
CONCLUSION: GzmK+CD8+ T cells and their senescent counterparts are not merely biomarkers of disease activity but may function as extracellular proinflammatory effectors that amplify the TNF-α-mediated inflammatory loop in BD. Targeting the GzmK-senescence axis represents a promising therapeutic strategy for managing chronic inflammation in BD.