Current opinion in HIV and AIDS · 2020
Opening the HIV envelope: potential of CD4 mimics as multifunctional HIV entry inhibitors.
СтатьяПоддержка NIH: внешняя программаПоддержка правительства СШАОбзорНазвание и аннотация: Перевод пока не подготовлен
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Laumaea Annemarie, Smith Amos B, Sodroski Joseph, Finzi Andrés
Аннотация
PURPOSE OF REVIEW: Close to 2 million individuals globally become infected with HIV-1 each year and just over two-thirds will have access to life-prolonging antivirals. However, the rapid development of drug resistance creates challenges, such that generation of more effective therapies is not only warranted but a necessary endeavour. This review discusses a group of HIV-1 entry inhibitors known as CD4 mimics which exploit the highly conserved relationship between the HIV-1 envelope glycoprotein and the receptor, CD4.
RECENT FINDINGS: We review the structure/function guided evolution of these inhibitors, vital mechanistic insights that underpin broad and potent functional antagonism, recent evidence of utility demonstrated in animal and physiologically relevant in-vitro models, and current progress towards effective new-generation inhibitors.
SUMMARY: The current review highlights the promising potential of CD4 mimetics as multifunctional therapeutics.
RECENT FINDINGS: We review the structure/function guided evolution of these inhibitors, vital mechanistic insights that underpin broad and potent functional antagonism, recent evidence of utility demonstrated in animal and physiologically relevant in-vitro models, and current progress towards effective new-generation inhibitors.
SUMMARY: The current review highlights the promising potential of CD4 mimetics as multifunctional therapeutics.