Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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Miyagawa Toji, Brushaber Danielle, Syrjanen Jeremy, Kremers Walter, Fields Julie, Forsberg Leah K, Heuer Hilary W, Knopman David, Kornak John, Boxer Adam, Rosen Howard J, Boeve Bradley F, Appleby Brian, Bordelon Yvette, Bove Jessica, Brannelly Patrick, Caso Christina, Coppola Giovanni, Dever Reilly, Dheel Christina, Dickerson Bradford, Dickinson Susan, Dominguez Sophia, Domoto-Reilly Kimiko, Faber Kelley, Ferrell Jessica, Fishman Ann, Fong Jamie, Foroud Tatiana, Gavrilova Ralitza, Gearhart Debra, Ghazanfari Behnaz, Ghoshal Nupur, Goldman Jill S, Graff-Radford Jonathan, Graff-Radford Neill, Grant Ian, Grossman Murray, Haley Dana, Hsiung Robin, Huey Edward, Irwin David, Jones David, Jones Lynne, Kantarci Kejal, Karydas Anna, Kaufer Daniel, Kerwin Diana, Kraft Ruth, Kramer Joel, Kukull Walter, Litvan Irene, Lucente Diane, Lungu Codrin, Mackenzie Ian, Maldonado Miranda, Manoochehri Masood, McGinnis Scott, McKinley Emily, Mendez Mario F, Miller Bruce, Multani Namita, Onyike Chiadi, Padmanabhan Jaya, Pantelyat Alexander, Pearlman Rodney, Petrucelli Leonard, Potter Madeline, Rademakers Rosa, Ramos Eliana M, Rankin Kate, Rascovsky Katya, Roberson Erik D, Rogalski Emily, Sengdy Pheth, Shaw Leslie, Tartaglia Maria C, Tatton Nadine, Taylor Joanne, Toga Arthur, Trojanowski John Q, Wang Ping, Weintraub Sandra, Wong Bonnie, Wszolek Zbigniew
Аннотация
METHODS: The CDR plus NACC FTLD rating was applied to 970 sporadic and familial participants from the baseline visit of Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS). Each of the eight domains of the CDR plus NACC FTLD was equally weighed in determining the global score. An interrater reliability study was completed for 40 participants.
RESULTS: The CDR plus NACC FTLD showed very good interrater reliability. It was especially useful in detecting clinical features of mild non-fluent/agrammatic variant primary progressive aphasia participants.
DISCUSSION: The global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders.