Zhonghua bing li xue za zhi = Chinese journal of pathology · 1997
[Severe combined immunodefficiency disease, 4 autopsy case reports].
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Yan P, Chen G, Zhang M
Аннотация
OBJECTIVE: To study the pathological changes of severe combined immunodefficiency disease (SCID).
METHODS: 4 cases with SCID proven by autopsy examination.
RESULTS: All patients were male with an average age of 5 moths. The major clinical manifestations included severe repeated infection with bacteria, virus, fungi and pneumocystis carinii. Autopsy examination revealed hypoplasia of thymus, spleen and lymph nodes. 1 case died from pneumocystis carinii pneumonia and BCG vaccine disease, 2 cases died of severe general infection and 1 case died from large cell lymphoma.
CONCLUSIONS: The main diagnosis criteria for SCID are hypoplasia of both T and B lymphocytes, the pathologic changes of SCID are very complex.
METHODS: 4 cases with SCID proven by autopsy examination.
RESULTS: All patients were male with an average age of 5 moths. The major clinical manifestations included severe repeated infection with bacteria, virus, fungi and pneumocystis carinii. Autopsy examination revealed hypoplasia of thymus, spleen and lymph nodes. 1 case died from pneumocystis carinii pneumonia and BCG vaccine disease, 2 cases died of severe general infection and 1 case died from large cell lymphoma.
CONCLUSIONS: The main diagnosis criteria for SCID are hypoplasia of both T and B lymphocytes, the pathologic changes of SCID are very complex.