Microbial drug resistance (Larchmont, N.Y.) · 2019
Distribution of Clinical NDM-1-Producing Gram-Negative Bacteria in Brazil.
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da Silva Isadora Rodrigues, Aires Caio Augusto Martins, Conceição-Neto Orlando Carlos, de Oliveira Santos Ivson Cassiano, Ferreira Pereira Natacha, Moreno Senna José Procópio, Carvalho-Assef Ana Paula D'Alincourt, Asensi Marise Dutra, Rocha-de-Souza Cláudio Marcos
Аннотация
New Delhi metallo-β-lactamase (NDM)-producing bacteria have been identified at a worrying rate in Brazil since 2013. Owing to the need to understand the extent of their spread, this study reports the dissemination of blaNDM in different species of Gram-negative bacilli in different regions and states of Brazil. A total of 81 isolates from nine states were studied, including 11 species. All isolates carried blaNDM-1 variant and were considered multidrug resistant. Colistin and amikacin were the agents with higher activity compared with the other drugs tested. The findings indicate that the NDM-1 enzyme is already widespread in the country.