Seminars in cell & developmental biology · 2019
The role of neurogenesis in neurorepair after ischemic stroke.
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод пока не подготовлен
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Marques Bruno L, Carvalho Gustavo A, Freitas Elis M M, Chiareli Raphaela A, Barbosa Thiago G, Di Araújo Armani G P, Nogueira Yanley L, Ribeiro Raul I, Parreira Ricardo C, Vieira Mariana S, Resende Rodrigo R, Gomez Renato S, Oliveira-Lima Onésia C, Pinto Mauro C X
Аннотация
Stroke consists of an abrupt reduction of cerebral blood flow resulting in hypoxia that triggers an excitotoxicity, oxidative stress, and neuroinflammation. After the ischemic process, neural precursor cells present in the subventricular zone of the lateral ventricle and subgranular zone of the dentate gyrus proliferate and migrate towards the lesion, contributing to the brain repair. The neurogenesis is induced by signal transduction pathways, growth factors, attractive factors for neuroblasts, transcription factors, pro and anti-inflammatory mediators and specific neurotransmissions. However, this endogenous neurogenesis occurs slowly and does not allow a complete restoration of brain function. Despite that, understanding the mechanisms of neurogenesis could improve the therapeutic strategies for brain repair. This review presents the current knowledge about brain repair process after stroke and the perspectives regarding the development of promising therapies that aim to improve neurogenesis and its potential to form new neural networks.