Rehabilitacion · 2025
[Benefits of a pulmonary rehabilitation program for patients with long COVID: Impact of initial severity, disease duration, and presentation type on clinical outcomes].
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Rodríguez-Hernández C, Guillén-Solà A, Curbelo Y G, Boza R, Acuña-Pardo C, Tejero-Sánchez M
Аннотация
INTRODUCTION: Two-thirds of patients infected with SARS-CoV-2 experience persistent symptoms after infection.
OBJECTIVES: To study the benefits of a respiratory rehabilitation program (RRP) in patients with long COVID and compare the results based on the time of evolution and clinical presentation.
METHODS: Post-hoc analysis of a prospective cohort of patients with long COVID. Changes were evaluated using the modified Medical Research Council (mMRC) dyspnea scale, the 6-minute walk test (6MWT), maximal inspiratory and expiratory pressures (maxIP and maxEP), and peripheral muscle strength. Statistical tests used: Chi-square, paired and independent t-Student tests, one-way ANOVA, and a general linear model.
RESULTS: Out of 158 patients referred to rehabilitation, 110 (mean age 58.1years; 57.3% women) started the RRP. After the intervention, significant improvements were observed: a reduction of 0.8 points (95%CI: -1.1 to -0.6) on the mMRC dyspnea scale, an increase of 19.6m (95%CI: -0.8 to 39.9) in the 6MWT, 16.8cmH2O (95%CI: 10.3 to 23.2) in maxIP, 22.5cmH2O (95%CI: 15.3 to 29.7) in maxEP, and 5.0kg (95%CI: 3.3 to 6.7) in quadriceps strength. Although these improvements were independent of infection onset and disease duration, patients from the first wave showed more modest improvements.
CONCLUSIONS: The RRP provides clinical and functional benefits for patients with long COVID, regardless of disease duration and initial severity of infection.
OBJECTIVES: To study the benefits of a respiratory rehabilitation program (RRP) in patients with long COVID and compare the results based on the time of evolution and clinical presentation.
METHODS: Post-hoc analysis of a prospective cohort of patients with long COVID. Changes were evaluated using the modified Medical Research Council (mMRC) dyspnea scale, the 6-minute walk test (6MWT), maximal inspiratory and expiratory pressures (maxIP and maxEP), and peripheral muscle strength. Statistical tests used: Chi-square, paired and independent t-Student tests, one-way ANOVA, and a general linear model.
RESULTS: Out of 158 patients referred to rehabilitation, 110 (mean age 58.1years; 57.3% women) started the RRP. After the intervention, significant improvements were observed: a reduction of 0.8 points (95%CI: -1.1 to -0.6) on the mMRC dyspnea scale, an increase of 19.6m (95%CI: -0.8 to 39.9) in the 6MWT, 16.8cmH2O (95%CI: 10.3 to 23.2) in maxIP, 22.5cmH2O (95%CI: 15.3 to 29.7) in maxEP, and 5.0kg (95%CI: 3.3 to 6.7) in quadriceps strength. Although these improvements were independent of infection onset and disease duration, patients from the first wave showed more modest improvements.
CONCLUSIONS: The RRP provides clinical and functional benefits for patients with long COVID, regardless of disease duration and initial severity of infection.