Human vaccines & immunotherapeutics · 2026
Personalized treatment of HER2-positive lung adenocarcinoma using Human Organoid Drug Sensitivity Test.
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Luan Tao, Fu Suneng, Liu Weiting, Wang Shuaiying, Xie Xiaohong, Lin Xinqing, Chenli Zekun, Wang Liqiang, Ma Kangjing, Ma Hongbin, Mo Junyi, Yu Baodan, Yang Qingqing, Xu Yilin, Jin Hui, Chen Qishan, Yao Leyang, Luan Yang, Zhong Nanshan, Lv Qun, Zhang Yunhui, Zhou Chengzhi
Аннотация
Human Epidermal Growth Factor Receptor 2 (HER2) mutations account for approximately 3% of non-small cell lung cancer (NSCLC) patients. Currently, targeted therapies for HER2-mutant NSCLC include HER2 tyrosine kinase inhibitors (TKIs) and HER2 Antibody-drug conjugates (ADC). However, resistance often develops, and effective treatments for HER2 mutations remain lacking. We report a case of HER2-mutant lung adenocarcinoma where the patient developed resistance and severe interstitial lung disease following antibody-drug conjugate therapy. A highly biomimetic Human Organoid (HO) platform was employed to screen potential therapeutic options for the patient. The HO results indicated efficacy of Sunvozertinib and ineffectiveness of ADC, with maximum half-maximal inhibitory concentration (IC50) values of 0.28 and 2.96, respectively. This case demonstrates the potential of Human Organoid Drug Sensitivity Test (HO-DST) to guide effective salvage therapy, bridging the gap between genomic profiling and functional drug response in precision oncology.