Diagnostic Evaluation and Clinical Findings in Children With Persistent Tachypnea of Infancy/Neuroendocrine Cell Hyperplasia of Infancy: A European Multicenter Retrospective Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Marczak Honorata, Krenke Katarzyna, Griese Matthias, Peradzyńska Joanna, Lange Joanna, Kulus Marek, Grochowska Magdalena, Seidl Elias, Dubus Jean-Christophe, Rodler Julia, Schwerk Nicolaus, Carlens Julia, Breuer Oded, Hevroni Avigdor, Castillo-Corullón Silvia, Aldeco Malena, Buchvald Frederik Fouirnaies, Nielsen Kim G, Mayell Sarah, Torrent Alba, Bravo-López Maynor, Regamey Nicolas, Stehling Florian, Latzin Philipp, Zschocke Anna, Hatziagorou Elpis, Ayats Roser, Eyüboğlu Tuğba Şişmanlar, Erdem Ela, Proesmans Marijke, Cunningham Steve, Moriki Dafni, Pekcan Sevgi, Cobanoglu Nazan, Naehrlich Lutz, Lex Christiane, Ullmann Nicola, Baden Winfried, Krikovszky Dora, Gaboli Mirella, Monge Nuria Diez, Vivas David Naranjo, Rubak Sune Leisgaard Mørck, Willemse Brigitte, Petrarca Laura, Wiemers Anna, Schramm Dirk, Mueller Christoph, Prenzel Freerk, Koucky Vaclav, López-Andreu Juan A, Nathan Nadia
Аннотация
RESEARCH QUESTION: Are the clinical presentation and the diagnostic approach different in patients with PTI/NEHI among European countries?
STUDY DESIGN AND METHODS: This was a European multicenter, retrospective, observational study. Data on clinical characteristics and diagnostic strategies in patients with PTI/NEHI were analyzed and compared across participating countries.
RESULTS: The study included 378 children with PTI/NEHI from 17 countries (63.5% male, 97.4% White) who received a diagnosis at a median age of 9 months (interquartile range, 6-13 months). The most common baseline symptoms were tachypnea, chest retractions, crackles on auscultation, hypoxemia, and failure to thrive. High-resolution CT (HRCT) imaging was performed in all patients, with most undergoing chest radiography, echocardiography, and immunology tests. Lung biopsy was carried out in 23.5% of patients, with a decreasing trend over time and variation by country; its use was associated with longer diagnostic delay. Histopathologic examination showed a hyperplasia of pulmonary neuroendocrine cells in 52.8% of patients. Genetic testing was rare, and its application varied significantly among countries. Additional investigations that do not have an established role, such as assessment for gastroesophageal reflux disease and OSA, infant pulmonary function tests, and lung ultrasound, were limited to single countries.
INTERPRETATION: Diagnosis of PTI/NEHI relies on clinical symptoms and HRCT imaging results, with lung biopsies less commonly performed. Differences exist among countries regarding the number and type of investigations. A need exists for guidelines that will standardize the diagnostic approach.