BMC ophthalmology · 2023
Local ocular safety of the subconjunctival injection of cetuximab in rabbits.
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Aghaei Hossein, Kheirkhah Ahmad, Alizadeh Ali Mohammad, Es'haghi Acieh, Aliakbar-Navahi Roshanak, Keikha Zahra, Chaibakhsh Samira
Аннотация
BACKGROUND: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits.
METHODS: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining.
RESULTS: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab.
CONCLUSION: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.
METHODS: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining.
RESULTS: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab.
CONCLUSION: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe.