Effect of Dexmedetomidine Plus Propofol versus Propofol Alone on Postoperative Anxiety and Depression, Efficacy, and Satisfaction in Patients who Undergo Painless Induced Abortion.

Dexmedetomidine-containing anesthetic regimes improve satisfaction and reduce postoperative mental disorders, but relevant evidence in patients who undergo painless induced abortion is scarce. This study intended to compare the effect of dexmedetomidine combined with propofol and propofol alone on postoperative anxiety and depression, efficacy, and satisfaction in patients who underwent painless induced abortion. A total of 142 patients who underwent painless induced abortion were divided into the Dexmedetomidine plus propofol group (N = 65) and Propofol group (N = 77) according to the actual anesthesia method. In the Dexmedetomidine plus propofol group, 0.3-0.6 μg/kg dexmedetomidine was intravenously pumped within 10 minutes before anesthesia induction. In both groups, 2.0 mg/kg propofol was intravenously administrated for anesthesia induction, and 20-40 mg of propofol was added each time for anesthesia maintenance during surgery. Awake time (7.5 ± 3.1 vs. 8.8 ± 3.2 min) (P = 0.017) and propofol dose (124.7 ± 22.1 vs. 139.8 ± 23.5 mg) (P < 0.001) were decreased in the Dexmedetomidine plus propofol group compared to the Propofol group. Postoperative Hospital Anxiety and Depression (HADS)-anxiety score was numerically lower in the Dexmedetomidine plus propofol group than in the Propofol group (5.2 ± 2.3 vs. 5.9 ± 2.8) (P = 0.087). The overall satisfaction rate was higher in the Dexmedetomidine plus propofol group than in the Propofol group (87.7% vs. 72.7%) (P = 0.028), which was further validated by multivariate logistic regression analysis. In conclusion, dexmedetomidine plus propofol improves satisfaction compared to propofol alone in patients receiving painless induced abortion.