Frontiers in cell and developmental biology · 2021
Establishment and Characterization of a HER2-Positive Cell Line Derived From the Pleural Effusion of a Drug-Resistant Breast Cancer Patient.
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Li Zhaoqing, Zhuo Wenying, Chen Lini, Zhang Xun, Chen Cong, Hu Dengdi, Chen Yongxia, Yang Jingjing, Zhou Yulu, Mao Misha, Xu Ling, Ju Siwei, Shen Jun, Wang Qinchuan, Dong Minjun, Xie Shuduo, Zhou Jichun, Wang Linbo
Аннотация
Drug resistance is a daunting challenge in the treatment of breast cancer, making it an urgent problem to solve in studies. Cell lines are important tools in basic and preclinical studies; however, few breast cell lines from drug-resistant patients are available. Herein, we established a novel HER2-positive breast cancer cell line from the pleural effusion of a drug-resistant metastatic breast cancer patient. This cell line has potent proliferative capability and tumorigenicity in nude mice but weak invasive and colony-forming capability. The molecular subtype of the cell line and its sensitivity to chemotherapeutics and HER2-targeting agents are different from those of its origin, suggesting that the phenotype changes between the primary and metastatic forms of breast cancer.