Annals of plastic surgery · 2025
Efficacy of Corneal Neurotization Surgery in Eyes With Neurotrophic Keratopathy: A Systematic Review and Meta-Analysis.
СтатьяСистематический обзорМетаанализПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Molinari Maria Eduarda, Huntermann Ramon, Pedrotti Chavez Matheus, Cristiane Lopes Samantha, de Oliveira Coronel Camacho Alex
Аннотация
PURPOSE: Corneal neurotization (CN) restores innervation to anesthetic corneas, often caused by neurotrophic keratopathy (NK), using healthy donor nerves or grafts. Despite promising outcomes, its efficacy remains unclear. We conducted a meta-analysis to assess the efficacy of CN in eyes with NK and its influence on postoperative outcomes.
METHODS: We systematically searched PubMed, EMBASE, and Cochrane. We calculated mean differences (MDs) with 95% confidence intervals (CIs) for continuous outcomes, following PRISMA guidelines. We used the R software for statistical analysis.
RESULTS: We included 17 studies (232 eyes; mean follow-up: 19.07 ± 7.45 months). CN improved best-corrected visual acuity (MD: -0.44; 95% CI: -0.66 to -0.21; P < 0.01; I2 = 88.7%), CS (MD: 32.42 mm; 95% CI: 27.45 to 37.38; P < 0.001), corneal nerve fiber density (MD: 12.15 n/mm 2 ; 95% CI: 5.09 to 19.20; P < 0.001), corneal nerve branch density (MD: 18.88 n/mm 2 ; 95% CI: 8.89 to 28.87; P < 0.001), and corneal nerve fiber length (MD: 9.40 mm/mm 2 ; 95% CI: 6.31 to 12.50; P < 0.001) and corneal nerve total branch density (MD: 25.48 n/mm 2 ; 95% CI: 14.09 to 36.87; P < 0.001). CN also reduced Mackie scores (MD: -1.20; 95% CI: -1.42 to -0.99; P < 0.001).
CONCLUSIONS: CN enhances both corneal function and innervation. These findings support CN as a promising and effective approach for restoring corneal function in NK.
METHODS: We systematically searched PubMed, EMBASE, and Cochrane. We calculated mean differences (MDs) with 95% confidence intervals (CIs) for continuous outcomes, following PRISMA guidelines. We used the R software for statistical analysis.
RESULTS: We included 17 studies (232 eyes; mean follow-up: 19.07 ± 7.45 months). CN improved best-corrected visual acuity (MD: -0.44; 95% CI: -0.66 to -0.21; P < 0.01; I2 = 88.7%), CS (MD: 32.42 mm; 95% CI: 27.45 to 37.38; P < 0.001), corneal nerve fiber density (MD: 12.15 n/mm 2 ; 95% CI: 5.09 to 19.20; P < 0.001), corneal nerve branch density (MD: 18.88 n/mm 2 ; 95% CI: 8.89 to 28.87; P < 0.001), and corneal nerve fiber length (MD: 9.40 mm/mm 2 ; 95% CI: 6.31 to 12.50; P < 0.001) and corneal nerve total branch density (MD: 25.48 n/mm 2 ; 95% CI: 14.09 to 36.87; P < 0.001). CN also reduced Mackie scores (MD: -1.20; 95% CI: -1.42 to -0.99; P < 0.001).
CONCLUSIONS: CN enhances both corneal function and innervation. These findings support CN as a promising and effective approach for restoring corneal function in NK.