Journal of endodontics · 2012
Apical periodontium response to enamel matrix derivative as an intracanal medication in rat immature teeth with pulp necrosis: radiographic and histologic findings.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Scarparo Roberta Kochenborger, Dondoni Lenara, Böttcher Daiana Elisabeth, Grecca Fabiana Soares, Figueiredo Jose A P, Batista Eraldo L
Аннотация
INTRODUCTION: The aim of this study was to evaluate the enamel matrix derivative (EMD) biomaterial in nonvital immature teeth.
METHODS: To arrest root development, pulpectomies were performed in the lower first molars of 36 4-week-old rats; the cavities were left exposed to the oral environment for 3 weeks. Then, chemical disinfection was performed, and triple antibiotic paste (TAP) or EMD was applied in the root canals. A control group did not receive any treatment. Radiographic and histological data were evaluated after 3 and 6 weeks.
RESULTS: At 3 weeks, TAP promoted a milder inflammatory response and increased root lengths compared with the control group. At 6 weeks, root development and reduced periapical lesions could be observed in both test groups, mainly because of the deposition of a cementum-like tissue. EMD promoted narrower canals compared with TAP (P < .05).
CONCLUSIONS: EMD deserves attention as a potential tool in the treatment of nonvital immature teeth. The ingrowth of cementum-like tissues into canal spaces favored dental wall thickness and may contribute to tooth resistance and support.
METHODS: To arrest root development, pulpectomies were performed in the lower first molars of 36 4-week-old rats; the cavities were left exposed to the oral environment for 3 weeks. Then, chemical disinfection was performed, and triple antibiotic paste (TAP) or EMD was applied in the root canals. A control group did not receive any treatment. Radiographic and histological data were evaluated after 3 and 6 weeks.
RESULTS: At 3 weeks, TAP promoted a milder inflammatory response and increased root lengths compared with the control group. At 6 weeks, root development and reduced periapical lesions could be observed in both test groups, mainly because of the deposition of a cementum-like tissue. EMD promoted narrower canals compared with TAP (P < .05).
CONCLUSIONS: EMD deserves attention as a potential tool in the treatment of nonvital immature teeth. The ingrowth of cementum-like tissues into canal spaces favored dental wall thickness and may contribute to tooth resistance and support.
Предметные рубрики MeSH
AnimalsAnti-Bacterial AgentsCementogenesisCiprofloxacinDental CementumDental Enamel ProteinsDental Pulp CavityDental Pulp NecrosisDentin, SecondaryDrug CombinationsImage Processing, Computer-AssistedMaleMetronidazoleMinocyclineOdontogenesisPeriapical PeriodontitisPeriapical TissuePeriodontal LigamentRadiography, Dental, DigitalRatsRats, WistarRoot Canal IrrigantsTime FactorsTooth ApexTooth, Nonvital