Oral surgery, oral medicine, oral pathology and oral radiology · 2025
A comparative analysis of DNA content and cell cycle phases in pleomorphic adenoma and carcinoma ex pleomorphic adenoma.
СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Maciel Tayná Figueiredo, Gonçalves Moisés Willian Aparecido, Scarini João Figueira, Vieira Gustavo de Souza, de Lima-Souza Reydson Alcides, Lavareze Luccas, Kimura Talita de Carvalho, Egal Erika Said Abu, Altemani Albina, Sperandio Marcelo, Mariano Fernanda Viviane
Аннотация
OBJECTIVE: This study aimed to analyze the DNA ploidy profile of pleomorphic adenoma (PA) using flow cytometry, with a particular focus on its malignant transformation.
STUDY DESIGN: Tissue samples were obtained from normal glands, primary and recurrent PA, and carcinoma ex PA (CXPA) (residual PA and malignant areas) for analysis. The data were analyzed using dedicated software and relevant increased literature resources.
RESULTS: The study revealed a decline in the number of cells in the G1 phase and an increase in those in the 5cER phase in CXPA compared to their benign counterparts.
CONCLUSIONS: DNA content by flow cytometry could be a valuable tool to aid in detecting CXPA early and to differentiate it from PA when routine histologic features are insufficient.
STUDY DESIGN: Tissue samples were obtained from normal glands, primary and recurrent PA, and carcinoma ex PA (CXPA) (residual PA and malignant areas) for analysis. The data were analyzed using dedicated software and relevant increased literature resources.
RESULTS: The study revealed a decline in the number of cells in the G1 phase and an increase in those in the 5cER phase in CXPA compared to their benign counterparts.
CONCLUSIONS: DNA content by flow cytometry could be a valuable tool to aid in detecting CXPA early and to differentiate it from PA when routine histologic features are insufficient.